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Planta Med 1983; 47(2): 100-102
DOI: 10.1055/s-2007-969962
Research Articles

© Hippokrates Verlag Stuttgart

Studies on Cryptolepine

Cryptolepine Antagonism of Noradrenaline and Modification of this Effect by Calcium Ions and Prostaglandine2 on Rat Isolated Mesenteric ArteryB. K. Noamesi, S. O. A. Bamgbose
  • Department of Pharmacology, College of Medicine, University of Lagos, Lagos, Nigeria
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Publication History

1980

1982

Publication Date:
26 March 2007 (online)

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Abstract

Cryptolepine;(1 to 8 µg ml-1) concentration dependently and competitively (pA2=6.40 ± 0.03, slope = 1.0) antagonised the vasoconstrictor effect of noradrenaline on the isolated perfused rat mesenteric artery, without producing vasodilatation. Prostaglandin E2 (2.5 µg ml-1) completely reversed cryptolepine block of the response of the artery to noradrenaline during normal Kreb's solution perfusion, but failed to reverse cryptolepine block of the response of the tissue in Ca2+ - free Kreb's perfusion medium. Increasing the Ca2+ concentration from zero did not restore the reversal of the cryptolepine blockade. It is suggested that Ca2+ ions play a significant role in the prostaglandin E2 induced reversal of cryptolepine block of noradrenaline vasoconstrictor response of the tissue.

Key Word Index

Cryptolepine - Prostaglandin E2 - Ca2+ ions - Noradrenaline - Mesenteric artery - Antagonism - Potentiation - Reversal