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Planta Med 1983; 47(3): 141-147
DOI: 10.1055/s-2007-969973
Research Articles

© Hippokrates Verlag Stuttgart

On the Active Principles of the Euphorbiaceae

VI: Isolation and Biological Activities of Seven Milliamines from Euphorbia milii[1] A. Marston, E. Hecker*
  • Institut für Biochemie, Deutsches Krebsforschungszentrum Heidelberg, Federal Republic of Germany
* Dedicated to Prof. Dr. Drs. mult. h.c. A. Butenandt on the occasion of his 80th birthday.
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Publication History

1982

Publication Date:
26 March 2007 (online)

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Abstract

Three previously known ingenol esters, milliamines A-C and four new ingenol esters, milliamines D-G, all containing anthraniloyl tripeptides in various positions of ingenol, were isolated from roots and stems of Euphorbia milii, using a combination of counter-current distribution, preparative TLC and preparative HPLC. All the esters were fully characterised and showed irritant activity on the mouse ear. Neither milliamine A nor milliamine C (the most irritant ester) was a tumour promoter on mouse back skin.

Key Word Index

Euphorbia milii - Euphorbiaceae - Ingenol Esters - Irritation

1 For part V of the series, see loc. cit. [1].

1 For part V of the series, see loc. cit. [1].