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J Reconstr Microsurg 2007; 23(2): 099-105
DOI: 10.1055/s-2007-970190
Copyright © 2007 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Expansion of Surviving Skin Paddle of Neurocutaneous Island Flaps in Rats by VEGF

Gulsum Tetik Menevse1 , Kemal Islamoglu1 , Halil Ege Ozgentas1
  • 1Department of Plastic and Reconstructive Surgery, Antalya, Turkey
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Publikationsverlauf

Accepted: October 11, 2006

Publikationsdatum:
01. März 2007 (online)

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ABSTRACT

The purpose of this study was to investigate whether vascular endothelial growth factor (VEGF) can enlarge the skin paddles of neurocutaneous flaps in rats. Wistar albino rats were used in four groups: Group 1, (n = 10): neurocutaneous island flap; Group 2, (n = 10): neurocutaneous island flap, surgical delay; Group 3, (n = 10): neurocutaneous island flap, VEGF; Group 4, (n = 10): graft. A 3 × 3-cm, neurocutaneous island flap was elevated on the anterolateral skin of the thigh of the rats. The surviving flap areas were 29.7 ± 1.43 percent in Group 1, 41.3 ± 3.24 percent in Group 2, 94.2 ± 1.46 percent in Group 3. There were no surviving areas in Group 4. The vascular networks of Group 3 animals were more intensive and diffused on microangiography and the histopathologic findings were better in this group. The surviving flap areas in Group 3 animals were enlarged approximately three times over the original size.

KEYWORDS

VEGF - flap - neurocutaneous - paddle expansion

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Kemal IslamogluM.D. 

Department of Plastic Reconstructive Surgery

Akdeniz University School of Medicine, 07059 Antalya, Turkey