Catalytic Arylations with Challenging Substrates: From Air-Stable HASPO Preligands to Indole Syntheses and C-H-Bond Functionalizations

Lutz Ackermann

doi:10.1055/s-2007-970744

ACCOUNT

Catalytic Arylations with Challenging Substrates: From Air-Stable HASPO Preligands to Indole Syntheses and C-H-Bond Functionalizations

Lutz Ackermann*
Ludwig-Maximilians-Universität München, Department Chemie und Biochemie, Butenandtstraße 5-13, Haus F, 81377 München, Germany
Fax: +49(89)218077425; e-Mail: Lutz.Ackermann@cup.uni-muenchen.de;

Abstract

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Abstract

The development of novel ligands and their applications to transition-metal catalysis performed in our laboratory are summarized. These studies include the use of air-stable, modular heteroatom-substituted secondary phosphine oxides (HASPO) in cross-coupling reactions of challenging substrates, such as aryl and vinyl chlorides, fluorides, and tosylates.

1 Introduction
2 Aryl Chlorides for Efficient Indole Syntheses
2.1 Hydroamination-Heck Reaction Sequence for Regioselective Indole Syntheses with 2-Chloroanilines
2.2 2-Alkynylchloroarenes for Efficient Indole Syntheses
2.3 Multicomponent Indole Synthesis
3 Air-Stable Heteroatom-Substituted Secondary Phosphine Oxide (HASPO) Preligands
3.1 Introduction
3.2 Diaminooxophosphine (daop) Ligands
3.3 Diaminochlorophosphine Preligand
3.4 Heteroatom-Substituted Secondary Phosphine Oxides (HASPO)
4 C-H-Bond Functionalization
4.1 Introduction
4.2 Intermolecular Direct Arylation Reactions via C-H-Bond Functionalization with Chlorides
4.3 Intermolecular Direct Arylation Reactions via C-H-Bond Functionalization with Tosylates
5 Summary

Key words

C-H-bond functionalization - cross-coupling - indoles - ligands - phosphorus

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Referenzen

References and Notes

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