Synthesis of 2-Aza-1-cyano-4-hydroxyanthraquinones

Sven Claessens; Jan Jacobs; Norbert De Kimpe

doi:10.1055/s-2007-970778

LETTER

Synthesis of 2-Aza-1-cyano-4-hydroxyanthraquinones

Sven Claessens, Jan Jacobs, Norbert De Kimpe*
Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
Fax: +32(9)2646243; e-Mail: norbert.dekimpe@UGent.be;

Abstract

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Abstract

Phthalide annulation of 2-alkylpyridin-3-ones results in the formation of the unexpected 2-aza-1-cyano-4-hydroxy-anthraquinones, the cyano moiety originating from the 3-cyanophthalide. These compounds hold great potential against Epstein-Barr Virus Early Antigen (EBV-EA) activation and as antimicrobial compounds

Key words

quinones - annulations - antiviral - phthalide - aza-anthraquinones

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