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Planta Med 1982; 46(12): 219-220
DOI: 10.1055/s-2007-971218
DOI: 10.1055/s-2007-971218
Research Articles
© Hippokrates Verlag Stuttgart
Hemmung des γ-Aminobuttersäureabbaus durch Valerensäurederivate
Inhibition of γ-Aminobutyric Acid Catabolism by Valerenic Acid DerivativesFurther Information
Publication History
1982
Publication Date:
29 March 2007 (online)
Abstract
The enzym system 2-oxoglutarataminotransferase/semisuccinaldehydoxireductase (E. C. 2.6.1.19/E.C. 1.2.1.16, Gabase) catalyzing the catabolism of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) is inhibited by mmol/l concentrations of valerenolic acid (20%) and acetylvalerenolic acid (38%). 1 mmol/l L-glutamic acid inhibited 59%, 0.1 mmol/l chlorogenic acid 69%.
Key Word Index
Valeriana officinalis - Valerianaceae - Valerenolic acid - γ-Amino-butyric acid (GABA) - Inhibitors of GABA-metabolism