Anti-Tumour Effects of the Sesquiterpene Lactone Parthenin

Daphne Mew; Felipe Balza; G. H. Neil Towers; Julia G. Levy

doi:10.1055/s-2007-971234

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Planta Med 1982; 45(5): 23-27
DOI: 10.1055/s-2007-971234

Research Articles

Anti-Tumour Effects of the Sesquiterpene Lactone Parthenin

Daphne Mew¹ , Felipe Balza² , G. H. Neil Towers² , Julia G. Levy¹

¹Department of Microbiology, University of British Columbia Vancouver, British Columbia, Canada
²Department of Botany, University of British Columbia Vancouver, British Columbia, Canada

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Publikationsverlauf

1981

Publikationsdatum:
29. März 2007 (online)

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Abstract

The anti-tumour effects of the sesquiterpene lactone, parthenin was studied both in vivo and in vitro. Parthenin showed marked cytotoxic activity to P815 mastocytoma, L1210 leukemia, and M-1 rhabdomyosarcoma cells in vitro. In vivo studies showed intraperitoneal drug administration could either cure mice or increase their survival time after intraperitoneal of subcutaneous injection with tumour cells.

Key Word Index

Parthenium hysterophorus - Asteraceae (Compositae) - Parthenin - Anti-tumour effect