Effets de trois Alcaloïdes Extraits du Strychnos usambarensis sur des Cellules Cancéreuses en Culture

R. Bassleer; M.-Cl Depauw-Gillet; Br Massart; J.-M. Marnette; Ph. Wiliquet; M. Caprasse; L. Angenot

doi:10.1055/s-2007-971260

Planta Med 1982; 45(6): 123-126
DOI: 10.1055/s-2007-971260

Research Articles

Effets de trois Alcaloïdes Extraits du Strychnos usambarensis sur des Cellules Cancéreuses en Culture

Effects of three Alkaloids Isolated from Strychnos usambarensis on Cancer Cells in CultureR. Bassleer¹ , M.-Cl. Depauw-Gillet¹ , Br. Massart¹ , J.-M. Marnette¹ , Ph. Wiliquet¹ , M. Caprasse² , L. Angenot²

¹Service d'Histologie et Cytologie, Faculté de Médecine, Université de Liège, Belgique
²Laboratoire de Pharmacognosie, Institut de Pharmacie, Université de Liège, Belgique

Abstract

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Abstract

The cellular effects of three alkaloids isolated from Strychnos usambarensis (melinonine F, strychnofoline, 18-19-dihydro-usambarine) are analysed by cytological methods in experimental animal tumours cultivated in vitro (B 16 mouse melanoma cells, mouse Ehrlich tumour cells ELT, HW 165 rat hepatoma). Under some experimental conditions, a certain degree of antimitotic activity is demonstrated.

Key Word Index

Strychnos usambarensis - Loganiaceae - Melinonine F - Strychnofoline - 18,19-dihydro-usambarine - anticancer agents - cancer cells

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