Abstract
In addition to the spasmolytic activity of Origanum compactum, the antagonistic effect of the main components thymol and carvacrol is investigated on the isolated guinea-pig ileum, induced by carbachol, histamine, 1,1-dimethyl-4-phenylpiperazinium iodide and BaCl2. The l-noradrenaline contractions on the rat vas deferens are also reduced by both of phenols and the Origanum macerate. pD′2 values and relative potency to papaverine illustrate the affinity of the isomers. It is concluded that thymol and carvacrol act as non-competitive antagonists and are not significantly different from each other.
Key Word Index
Origanum compactum - Labiatae - Thymol - Carvacrol - Papaverine - Antispasmodic activity
1 Part 1: Planta medica, 38, 317 (1980).
