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Planta Med 1982; 45(8): 224-228
DOI: 10.1055/s-2007-971377
Research Articles

© Hippokrates Verlag Stuttgart

Nachweis sedativ-hypnotischer Wirkstoffe im Hopfen

3. Mitteilung1: Der Gehalt von Hopfen und Hopfenzubereitungen an 2-Methyl-3-buten-2-olThe Sedativ-Hypnotic Principle of Hops3. Communication: Contents of 2-Methyl-3-butene-2-ol in Hops and Hop PreparationsR. Hänsel3 , R. Wohlfart3 2 , H. Schmidt4
  • 3Institut für Pharmakognosie und Phytochemie der Freien Universität Berlin
  • 4ZYMA GmbH, München
1 1. Mitteilung: [2] 2. Mitteilung: [3]2 Vorabveröffentlichung von Teilen der Dissertation von R. Wohlfart
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Publikationsverlauf

1981

Publikationsdatum:
29. März 2007 (online)

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Abstract

A gas chromatographic method for the quantitative evaluation of 2-methyl-3-butene-2-ol, a sedative hop constituent, is described. Depending on the storing time, the content of this compound was determined in a large number of hops, hop extracts, and drugs.

While only traces of the compounds were detected in fresh hops, the concentration continously increased after drying to reach maximum levels (approx. 0.15%) within 2 years of storing at room temperature, irrespective of the specific kind. Hop extracts standardized to alpha-acids, which are available on the market, were found to contain relatively small amounts of 2-methyl-3-butene-2-ol.

Only traces of the compounds were discovered in hop containing “sedative dragees”, whereas a relatively high concentration was found in a sedative bath preparation. Thus, pharmacologically relevant concentrations of 2-methyl-3-butene-2-ol can be reached in both tea and bath preparations. However, since there is a reason to suppose that 2-methyl-3-butene-2-ol may also be formed in vivo by metabolization of alpha-acids, negative conclusions as to the effectiveness of the dragees should not be drawn before completion of the current studies.

Key Word Index

Humulus lupulus - Cannabaceae - 2-Methyl-3-butene-2-ol - Hypnotic principle