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Planta Med 1982; 45(8): 234-236
DOI: 10.1055/s-2007-971379
Research Articles

© Hippokrates Verlag Stuttgart

Isolation of Drug Metabolism Modifiers from Roots of Angelica koreana*

W. S. Woo, Ch. K. Lee, K. H. Shin
  • Natural Products Research Institute, Seoul National University, Seoul, Korea
* Part 4 in the series: Studies on crude drugs acting on drug metabolizing enzymes. For part 3 see [1].
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Publication History

1981

Publication Date:
29 March 2007 (online)

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Abstract

Five coumarins altering rate of drug metabolism were isolated from the roots of Angelica koreana and identified as isoimperatorin, imperatorin, bergapten, oxypeucedanin and isooxypeucedanin.

These linear furanocoumarins inhibited hexobarbital metabolism in the first phase and accelerated it in the second phase.

Key Word Index

Angelica koreana - Apiaceae (Umbelliferae) - Coumarins - Drug metabolizing enzyme inhibitor