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Planta Med 1982; 45(8): 234-236
DOI: 10.1055/s-2007-971379
DOI: 10.1055/s-2007-971379
Research Articles
© Hippokrates Verlag Stuttgart
Isolation of Drug Metabolism Modifiers from Roots of Angelica koreana*
* Part 4 in the series: Studies on crude drugs acting on drug metabolizing enzymes. For part 3 see [1].Weitere Informationen
Publikationsverlauf
1981
Publikationsdatum:
29. März 2007 (online)
Abstract
Five coumarins altering rate of drug metabolism were isolated from the roots of Angelica koreana and identified as isoimperatorin, imperatorin, bergapten, oxypeucedanin and isooxypeucedanin.
These linear furanocoumarins inhibited hexobarbital metabolism in the first phase and accelerated it in the second phase.
Key Word Index
Angelica koreana - Apiaceae (Umbelliferae) - Coumarins - Drug metabolizing enzyme inhibitor