Anti-Inflammatory Activity of Piperonyl-4-Acrylic Isobutyl Amide, an Extractive from Zanthoxylum zanthoxyloides

Abstract

The anti-inflammatory activity of piperonyl-4-acrylicisobutyl-amide (fagaramide) has been studied. Fagaramide was effective against carrageenan paw oedema in rats and was approximately twenty times less potent than indomethacin, a non-steroidal anti-inflammatory agent. Fagaramide was effective against the prostaglandin phase of an acute experimental inflammatory reaction. It dose-dependently inhibited prostaglandin synthesis in vitro but had no effect on PGE₁ - induced potentiation of carrageenan oedema in indomethacin treated rats. It is thus suggested that at least part of the anti-inflammatory activity of fagaramide is mediated via inhibition of prostaglandin synthesis.

Key Word Index

Zanthoxylum zanthoxyloides - Rutaceae - Fagaramide - Piperonyl-4-Acrylic Isobutyl Amide - Anti-Inflammatory Activity