Effect of Calophyllolide, a Nonsteroidal Anti-Inflammatory Agent, on Capillary Permeability

Abstract

Calophyllolide, a nonsteroidal anti-inflammatory agent, was found to be effective in reducing the increased capillary permeability induced in mice by various chemical mediators involved in the inflammatory process viz. histamine (HA), 5-hydroxytryptamine (5-HT) and bradykinin (BK). Pretreatment with Calophyllolide (p. o.) afforded significant protection against induced increase in capillary permeability by HA (PD₅₀ 144.1 mg/kg), 5-HT (PD₅₀ 250.0 mg/kg) and BK (PD₅₀ 133.5 mg/kg). Clinical studies with Calophyllolide in different inflammatory disorders are warranted, in view of its very similar safety margin to oxyphenbutazone (21.4 mg/kg and 25 mg/kg respectively).

Calophyllum inophyllum - Guttiferae - Calophyllolide - Capillary Permeability