Phototoxic Furanoquinolines of the Rutaceae

G. H. N. Towers; E. A. Graham; I. D. Spenser; Z. Abramowski

doi:10.1055/s-2007-971690

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Planta Med 1981; 41(2): 136-142
DOI: 10.1055/s-2007-971690

Research Articles

Phototoxic Furanoquinolines of the Rutaceae

G. H. N. Towers¹ , E. A. Graham¹ , I. D. Spenser² , Z. Abramowski¹

¹Department of Botany, University of British Columbia, Vancouver, B.C., Canada V6T 2B1
²Department of Chemistry, McMaster University, Hamilton, Ontario, Canada L8S 4M1

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Publication History

Publication Date:
29 March 2007 (online)

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Abstract

Dictamnine, isodictamnine, 7-demethylskimmianine, maculosidine and maculine were shown to be phototoxic to certain bacteria and yeasts in long wave UV light. Dose response curves with dictamnine and 8-methoxypsoralen in UV light were compared using E. coli and Saccharomyces cerevisiae. In comparison with 8-methoxypsoralen higher concentrations of dictamnine are required to elicit a phototoxic response.

Key Word Index

Rutaceae - Furanoquinolines - Dictamnine - UV-Radiation - Phototoxicity - E. coli - Saccharomyces cerevisiae