Effects of Ginseng Saponins on the Actions of Adrenaline, ACTH and Insulin on Lipolysis and Lipogenesis in Adipose Tissue

H. Ohminami; Y. Kimura; H. Okuda; T. Tani; S. Arichi; T. Hayashi

doi:10.1055/s-2007-971726

Planta Medica, Inhaltsverzeichnis

Planta Med 1981; 41(4): 351-358
DOI: 10.1055/s-2007-971726

Research Articles

Effects of Ginseng Saponins on the Actions of Adrenaline, ACTH and Insulin on Lipolysis and Lipogenesis in Adipose Tissue

H. Ohminami¹ , Y. Kimura² , H. Okuda¹ , T. Tani² , S. Arichi¹ , T. Hayashi³

¹2nd Department of Medical Biochemistry, School of Medicine, Ehime University, Onsen-gun, Ehime, Japan
²The Research Institute of Oriental Medicine, School of Medicine, Kinki University, Minami-Kawachi-gun, Osaka, Japan
³Koshiro Chuji Shoten, Co. Ltd., Dosho-machi, Higashi-ku, Osaka, Japan

Abstract

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Abstract

Studies were carried out to clarify the effects of ginseng saponins on the actions of adrenaline, ACTH and insulin on lipolysis and lipogenesis in adipose tissue. None of the ginseng saponins tested in the present experiments affected lipolytic actions of adrenaline in fat cells. Adreno-corticotrophic hormone (ACTH)-induced lipolysis in fat cells was inhibited by ginsenoside Rbc group, Rb₁, Rb₂, Rc, Rg group, Re, Rg₁ and Rg₂. Insulin-stimulated lipogenesis in adipose tissue slices was significantly reduced by ginsenoside Rbc group, Rb₂, Rc, Rg group, Rg₁, Rg₂, and Rh₁, while ginsenoside Rb₁ and Re did not inhibit the lipogenesis. On the other hand propranolol inhibited both adrenaline and ACTH-induced lipolysis. In contrast to propranolol, ginsenosides Rb₁ and Re selectively inhibited ACTH-induced lipolysis and Rh₁ exclusively reduced lipogenesis in the presence of insulin.

Key Word Index

Panax ginseng - Araliaceae - Ginseng saponins - Adrenaline-induced lipolysis - ACTH-induced lipolysis - Insulin-stimulated lipogenesis - Fat cells

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