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Planta Med 1981; 41(4): 392-396
DOI: 10.1055/s-2007-971733
Research Articles

© Hippokrates Verlag Stuttgart

Studies on Cryptolepine

II: Inhibition of Carragenan Induced Oedema by CryptolepineS. O. A. Bamgbose, B. K. Noamesi
  • Department of Pharmacology, College of Medicine, University of Lagos, Lagos, Nigeria
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Publication History

Publication Date:
29 March 2007 (online)

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Abstract

The effects of Cryptolepine have been investigated on the carrageenan induced oedema in the rat hind paw, the rat isolated perfused stomach strip and the isolated perfused lizard lung preparation.

Cryptolepine (1-20 µg/ml-1) did not inhibit prostaglandin synthesis in the isolated lizard lung but it antagonised prostaglandin E2 and not 5-hydroxytryptamine on the rat isolated perfused stomach strip. It also antagonised histamine and acetylcholine on the isolated guineapig ileum.

Carrageenan induced oedema in the rat hind paw was inhibited by Cryptolepine (1, 5, 10 and 20 mg/kg-1). The inhibitory effect is probably receptor mediated.

Key Word Index

Cryptolepine - Prostaglandin - Carrageenan, Antiinflammation