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Am J Perinatol 2007; 24(5): 277-281
DOI: 10.1055/s-2007-972925
Copyright © 2007 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Celocentesis for In Utero Stem Cell Therapy: Where We Now Stand and Future Directions

Joaquin Santolaya-Forgas1 , Juan De Leon-Luis2 , Louise Wilkins-Haugh1
  • 1Center for Fetal Medicine and Prenatal Genetics, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
  • 2Amarillo Women's Health Research Institute, Department of Obstetrics and Gynecology, Texas Tech University and Health Science Center, Amarillo, Texas
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Publication History

Publication Date:
04 May 2007 (online)

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ABSTRACT

As the number of inborn errors of metabolism that can be diagnosed prenatally by direct DNA analysis increases, so will the number of patients interested in having prenatal diagnosis for these conditions. The phenotypic expression of these inherited inborn errors of metabolism in theory could be prevented by the in utero transplantation of donor stem cells. It is the authors' opinion that ultrasound-guided celocentesis performed in the timed-pregnant baboon animal model could have an important role for determining if stem cell transplantation in the nonfunctional immunocompetent embryo has any clinical potential.

KEYWORDS

First-trimester ultrasound - prenatal diagnosis - celocentesis - stem cell therapy - in utero gene therapy

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Joaquin Santolaya-ForgasM.D. Ph.D. 

Center for Fetal Medicine and Prenatal Genetics, Department of Obstetrics and Gynecology, Brigham and Women's Hospital

75 Francis Street, Boston, MA 02115