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Neuropediatrics 1997; 28(1): 18-20
DOI: 10.1055/s-2007-973658
Short communications

© Hippokrates Verlag GmbH Stuttgart

Cross-Species Homology of the CLN3 Gene

P. E. M. Taschner1 , Nanneke de Vos1 , M. H. Breuning1 , 2
  • 1Department of Genetics, Section of Human Genetics, Leiden University, Leiden,
  • 2Department of Clinical Genetics, Erasmus University Rotterdam, The Netherlands
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Publication History

Publication Date:
13 March 2007 (online)

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Abstract

A murine cDNA clone was isolated by screening a mouse cDNA library with the human CLN3 cDNA. Sequence analysis indicates that the corresponding CLN3 proteins are highly homologous. We have compared these with recently identified CLN3 sequences from the dog, the nematode C. elegans, and baker's yeast S. cerevisiae. The CLN3 protein is remarkably conserved across eukaryotic species. Several protein modification sites which may be crucial for the function of the protein are conserved.

Key words

Neuronal ceroid lipofuscinosis - Batten disease - NCL - CLN3 - Protein comparison - Mouse