Einfluss körperlicher Aktivität auf die Fettoxidation und Endothelfunktion bei Adipösen - eine randomisiert kontrollierte Studie

Zusammenfassung

Fragestellung: Welche Auswirkungen eines moderaten Ausdauertrainings unter Berücksichtigung der Intensität der höchsten Fettoxidation können auf die Fettoxidation und die Körperzusammensetzung sowie die Endothelfunktion bei Adipösen erwartet werden?

Material und Methode: 26 adipöse Probanden mit einem BMI über 30 kg/m² wurden randomisiert einer Trainings- und Kontrollgruppe zugeteilt. Die Probanden der Trainingsgruppe absolvierten für 12 Wochen mit der jeweils individuell bestimmten Intensität ihrer höchsten Fettoxidation drei Trainingseinheiten mit 45 Minuten/Wo. Zur Bestimmung der Fettoxidation diente ein Laufband-Belastungstest, die Beurteilung der Endothelfunktion erfolgte mit der Ultraschallmethode an der A. brachialis. Die Kontrollmessungen wurden in beiden Gruppen zu Beginn und Ende des 12 wöchigen Untersuchungsintervalls vorgenommen.

Ergebnisse: Im Gegensatz zur Kontrollgruppe verbesserte sich in der Trainingsgruppe die Endothelfunktion von 4.3±3.5 auf 6.9±2.7% signifikant (p=0.001). Ebenso erzielte die Trainingsgruppe eine signifikante (p=0.019) Verbesserung der flussmediierten Dilatation (FMD) und eine signifikant (p=0.025) höhere FMD. Die Fettoxidation verbesserte sich während aller drei Belastungsstufen (p=0.006; p=0.023; p=0.007) und die freie Fettmasse nahm signifikant (p=0.009) zu, wobei die Fettmasse gleichzeitig abnahm (p=0.003).

Schlussfolgerung: Ein zwölfwöchiges Ausdauertraining unter Berücksichtigung der individuellen Intensität der höchsten Fettoxidation verbessert auch ohne substantiellen Gewichtsverlust die Endothelfunktion und Fettoxidation bei adipösen Frauen und Männern.

Abstract

Purpose: What are the effects of moderate physical activity based on the intensity of the highest fat oxidation rate on endothelial function, fat oxidation and body composition in obese women and men?

Materials and Methods: 26 subjects with a BMI above 30 kg/m² were randomly assigned to a training and a control group. Subjects of the training group performed three training session per week for 45 minutes for 12 weeks based on their individually determined intensity of highest fat oxidation. Fat oxidation was determined during a treadmill test, the endothelial function was assessed by the ultrasound method on the A. brachialis. In both groups the control measurements were done at the beginning and at the end of the 12 weeks lasting intervention period.

Results: In contrast to the control group the training group improved endothelial function from 4.33.5 to 6.9±2.7% significantly (p=0.001). Furthermore the training group achieved a significantly (p=0.019) improved flow mediated dilatation (FMD) and a significant higher FMD. Fat oxidation rate improved during all three stages significantly (p=0.006; p=0.023; p=0.007) and fat free mass increased significantly (p=0.009) whereas body fat mass was reduced (p=0.003).

Conclusion: A training program of twelve weeks based on the intensity of the highest fat oxidation improves endothelial function and fat oxidation in obese women and men even without reduction in body weight.

Adipositas - körperliche Aktivität - Fettoxidation - Endothelfunktion

obesity - physical activity - fat oxidation - endothelial function

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