A Facile and General Synthesis of Rare l-Sugar Lactones

Abstract

A facile and general synthesis of rare l-sugar lactones from d-sugars by selectively inverting C-5 was developed. Selective 1-deacylation of sugar perpivaloates by hydroxylamine is described. More practically, β-d-glucose pentaacetate could be transformed to l-idono-1,4-lactones by this simple procedure.

Key words

l-sugar - aldonolactone - 1-deacylation

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