Kombinierte EEG- und Doppler-Methode zur Bestimmung der neurovaskulären Kopplung am visuellen Kortex des Menschen

Zusammenfassung

Zwischen der jeweilig lokalen Hirnaktivität und der regionalen Hirndurchblutung besteht eine enge Korrelation, die mit dem Begriff der neurovaskulären Kopplung beschrieben wird. In der folgenden Übersicht wollen wir ein kombiniertes EEG und transkranielles Dopplerverfahren vorstellen, mit dem die neurovaskuläre Kopplung unter klinischen Bedingungen einfach und zuverlässig am Menschen bestimmt werden kann. Im Falle der Differenzierung zwischen einer Alzheimer und vaskulären Demenz wollen wir die Vorzüge der neuen Methode darlegen.

Abstract

There is a tight coupling between neuronal activity and regional cerebral blood flow, which is called neurovascular coupling. In the following overview we will describe a combined EEG and transcranial Doppler approach that allows investigation of the neurovascular coupling in humans in an easy and accurate manner. In the case of the differentiation between Alzheimer's disease and a vascular type of dementia we wish to show the advantages of the new method.

Schlüsselwörter

Funktionelle transkrankielle Dopplersonographie - Visuell evozierte Potentiale - neurovaskuläre Kopplung - Hirndurchblutung - funktionelle Aktivierung

Key words

Functional transcranial Doppler - visual evoked potential - neurovascular coupling - cerebral blood flow - functional activation

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