Endomorphin-1, an Endogenous µ-Opioid Receptor-Selective Agonist, Stimulates Oxygen Consumption in Mice

A. Asakawa; A. Inui; N. Ueno; M. Fujimiya; M. A. Fujino; M. Kasuga

doi:10.1055/s-2007-978587

Hormone and Metabolic Research, Inhaltsverzeichnis

Horm Metab Res 2000; 32(2): 51-52
DOI: 10.1055/s-2007-978587

Originals Basic

Endomorphin-1, an Endogenous µ-Opioid Receptor-Selective Agonist, Stimulates Oxygen Consumption in Mice

A. Asakawa¹ , A. Inui¹ , N. Ueno¹ , M. Fujimiya² , M. A. Fujino³ , M. Kasuga¹

¹Second Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
²Department of Anatomy, Shiga University of Medical Science, Shiga, Japan
³First Department of Internal Medicine, Yamanashi Medical University, Yamanashi, Japan

Abstract

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This study was undertaken to investigate the effect of endogenous µ-receptor-selective peptide endomorphin 1, administered intracerebroventricularly, on oxygen consumption in mice. The intracerebroventricular injection of endomorphin 1 (3-30 nmol) significantly increased oxygen consumption in unrestrained mice. The effect of endomorphin 1 (30 nmol) was significantly antagonized by the simultaneous intraperitoneal administration of naloxone (100 nmol). These results suggest that endomorphin 1 stimulates oxygen consumption, and that the µ-opioid receptor influences energy balance in mice.

Key words

Endomorphin - Intracerebroventricular Injection - Mice - Oxygen Consumption - µ-Opioid Receptor

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