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Horm Metab Res 2000; 32(2): 51-52
DOI: 10.1055/s-2007-978587
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© Georg Thieme Verlag Stuttgart · New York

Endomorphin-1, an Endogenous µ-Opioid Receptor-Selective Agonist, Stimulates Oxygen Consumption in Mice

A. Asakawa1 , A. Inui1 , N. Ueno1 , M. Fujimiya2 , M. A. Fujino3 , M. Kasuga1
  • 1Second Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
  • 2Department of Anatomy, Shiga University of Medical Science, Shiga, Japan
  • 3First Department of Internal Medicine, Yamanashi Medical University, Yamanashi, Japan
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Publikationsverlauf

1999

1999

Publikationsdatum:
19. April 2007 (online)

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This study was undertaken to investigate the effect of endogenous µ-receptor-selective peptide endomorphin 1, administered intracerebroventricularly, on oxygen consumption in mice. The intracerebroventricular injection of endomorphin 1 (3-30 nmol) significantly increased oxygen consumption in unrestrained mice. The effect of endomorphin 1 (30 nmol) was significantly antagonized by the simultaneous intraperitoneal administration of naloxone (100 nmol). These results suggest that endomorphin 1 stimulates oxygen consumption, and that the µ-opioid receptor influences energy balance in mice.

Key words

Endomorphin - Intracerebroventricular Injection - Mice - Oxygen Consumption - µ-Opioid Receptor