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Horm Metab Res 2000; 32(2): 80-83
DOI: 10.1055/s-2007-978594
Originals Clinical

© Georg Thieme Verlag Stuttgart · New York

Lack of Association Between an ecNOS Gene Polymorphism and Diabetic Nephropathy in Type 2 Diabetic Patients with Proliferative Diabetic Retinopathy

H. Fujita1 , T. Narita1 , H. Meguro1 , T. Ishii1 , O. Hanyu2 , K. Suzuki2 , K. Kamoi3 , S. Ito1
  • 1Department of Geriatric Medicine, Akita University School of Medicine, Akita, Japan
  • 2First Department of Internal Medicine, Niigata University School of Medicine, Niigata, Japan
  • 3Nagaoka Red Cross Hospital, Niigata, Japan
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1998

1999

Publication Date:
19 April 2007 (online)

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The development of diabetic nephropathy shows remarkable variation among individuals. Therefore, not only hyperlgycemia but also genetic factors may contribute to the development of diabetic nephropathy. The aim of the present study was to examine the contribution of the 27-bp repeat polymorphism in intron 4 of the endothelial constitutive nitric oxide synthase gene (ecNOS4) to the development of diabetic nephropathy. For this purpose, we analyzed this polymorphism in 167 Japanese type 2 diabetic patients with proliferative diabetic retinopathy consisting of 102 patients with diabetic nephropathy (with macroalbuminuria) and 65 patients without diabetic nephropathy (with normoalbuminuria). The genotype and allele frequencies were not significantly different between patients with diabetic nephropathy and those without diabetic nephropathy (ecNOS4 “b/b” 79.4% vs. 84.6%, ecNOS4 “b/a” 20.6% vs. 15.4%, “b” allele 89.7% vs. 92.3%, “a” allele 10.3% vs. 7.7%). We conclude that the ecNOS4 polymorphism does not contribute to the development of diabetic nephropathy.

Key words

ecNOS Gene - DNA Polymorphism - Type 2 Diabetes - Diabetic Nephropathy - Proliferative Diabetic Retinopathy