Horm Metab Res 2000; 32(9): 339-342
DOI: 10.1055/s-2007-978649
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© Georg Thieme Verlag Stuttgart · New York

Nitric Oxide Decreases Insulin Resistance Induced by High-Fructose Feeding

Y. Oshida1 , 2 , Y. Tachi3 , Y. Morishita3 , K. Kitakoshi2 , N. Fuku2 , Y.-Q. Han2 , I. Ohsawa1 , 2 , Y. Sato1 , 2
  • 1Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya, Japan
  • 2Department of Sports Medicine, Graduate School of Medicine, Nagoya University, Nagoya, Japan
  • 3Nagoya University School of Medicine, Nagoya, Japan
Further Information

Publication History

2000

2000

Publication Date:
19 April 2007 (online)

The effect of nitric oxide (NO) on insulin resistance was studied in high-fructose-fed rats. A sequential hyperinsulinemic euglycemic clamp procedure was employed (insulin infusion rates: 3 and 30 mU/kg BW/min) in 12 high-fructose-fed rats and 12 chow-fed rats while awake. Half of the high-fructose-fed and the chow-fed rats, respectively, were continuously given sodium nitroprusside (SNP, 3 ng/kg BW/min) during the clamp study. Blood glucose was clamped at the fasting level in each rat. Plasma insulin levels during the 3 and 30 mU/kg BW/min insulin infusions were 30 and 400 µU/ml, respectively. Metabolic clearance rate of glucose (MCR) was regarded as an index of whole body insulin action. At both 3 and 30 mU/kg BW/min insulin infusions, high-fructose feeding showed a significant decrease in MCR compared with the chow-fed rats. However, decreased MCRs were stimulated by SNP administration and reached similar levels as the chow-fed rats. SNP infusion did not influence MCRs in the chow-fed rats. Therefore it could be concluded that NO can improve insulin resistance induced by high-fructose feeding.