Aminergic signaling in the CNS is terminated by clearance from the synapse via high-affinity transporter molecules in the presynaptic membrane. Relatively recent
sequence identification of these molecules has now permitted the initiation of studies
of regulation of transporter function at the cellular and systems levels. In vitro studies provide evidence that the transporters for dopamine, serotonin, and γ-aminobutyric
acid are substrates for regulation by protein kinase C signaling. In vivo studies provide evidence that insulin and adrenal and gonadal steroid hormones may
regulate the synthesis and activity of the transporters. Future directions should
permit evaluation of the role of endocrine regulation in neurotransmitter clearance,
and thus in the maintenance of normal CNS aminergic signaling.
Key words
Insulin - Glucocorticoids - Aldosterone - Transporters - Dopamine - Estrogen
