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Horm Metab Res 1999; 31(8): 476-477
DOI: 10.1055/s-2007-978778
Originals Clinical

© Georg Thieme Verlag Stuttgart · New York

Danazol and Multiple Hepatic Adenomas: Peculiar Clinical Findings in an Acromegalic Patient

E. De Menis, P. Tramontin, N. Conte
  • Department of Internal Medicine, Ospedale Regionale, Treviso, Italy
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Publication History

1998

1999

Publication Date:
20 April 2007 (online)

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Hepatic adenomas are rare tumors; they have been associated with the use of anabolic steroids. Acromegaly increases the overall risk of neoplasms. We report the case of a female acromegalic patient in whom multiple hepatic adenomas appeared soon after danazol treatment for uterine fibromatosis. Treatment of acromegaly with octreotide, followed by successfull selective pituitary adenomectomy, stabilized the number and the size of the liver tumors. We suggest that oversecretions of GH and IGF-I were strong promoting factors for liver tumorigenesis in this patient.

Key words

Acromegaly - Liver Adenoma - Danazol - Octreotide