Horm Metab Res 1998; 30(3): 141-145
DOI: 10.1055/s-2007-978853
Originals Clinical

© Georg Thieme Verlag Stuttgart · New York

Body Fat Distribution, Insulin Mediated Suppression of Non-esterified Fatty Acids and Plasma Triglycerides in Obese Subjects

L. Herranz1 , A. Zapata2 , C. Grande2 , A. Megia1 , L. F. Pallardo1
  • 1Department of Endocrinology, Hospital La Paz, Madrid, Spain
  • 2Department of Biochemistry, Hospital La Paz, Madrid, Spain
Further Information

Publication History

1997

1997

Publication Date:
20 April 2007 (online)

Triglyceride levels and free fatty acid metabolism are influenced by body fat distribution. To test whether the pattern of fat distribution in obese subjects results in distinct insulin mediated suppression of non-esterified fatty acids which could account for differences in plasma triglycerides, we studied 59 obese subjects who were classified according to waist-to-hip ratio. Non-esterified fatty acids and insulin response to a 75 g oral glucose tolerance test were higher in abdominal obesity. Total non-esterified fatty acids response, after adjustment for sex, showed a positive association with waist-to hip ratio (r = 0.292; p < 0.05). The abdominal obese group had higher fasting triglycerides (1.74 ± 0.83 versus 1.11 ± 0.71 mmol/L; p = 0.003) and lower glucose/insulin ratio (5.2 ± 2.3 versus 7.1 ± 2.4; p = 0.003). Stepwise multiple regression analysis showed that triglyceride levels are explained by fasting and 120 min non-esterified fatty acids and by glucose/insulin ratio. We conclude that abdominal obesity is associated with a higher resistance to insulin mediated suppression of non-esterified fatty acids in obese subjects. Variation of triglyceride concentrations in obesity is dependent on both fasting and 120 min non-esterified fatty acids as well as on insulin sensitivity to glucose utilization.