Comparison Between the Effects of D-Mannoheptulose and its Hexaacetate Ester upon D-Glucose Metabolism in Rat Erythrocytes

L. Ladrière; M. M. Kadiata; W. J. Malaisse

doi:10.1055/s-2007-978875

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 1998; 30(5): 244-245
DOI: 10.1055/s-2007-978875

Originals Experimental

Comparison Between the Effects of D-Mannoheptulose and its Hexaacetate Ester upon D-Glucose Metabolism in Rat Erythrocytes

L. Ladrière, M. M. Kadiata, W. J. Malaisse

Laboratory of Experimental Medicine, Brussels Free University, Brussels, Belgium

Abstract

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At a 2.0 mM concentration, D-mannoheptulose hexaacetate, but not unesterified D-mannoheptulose, inhibited the generation of radioactive acidic metabolites by rat erythrocytes exposed to D-[U-¹⁴C]glucose (8.3 mM). It is proposed that D-mannoheptulose hexaacetate represents a valuable tool to interfere with the phosphorylation of D-glucose in cell types otherwise resistant to the heptose.

Key words

Rat Erythrocytes - D-Glucose Metabolism - D-Mannoheptulose (Hexaacetate)

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