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DOI: 10.1055/s-2007-978940
© Georg Thieme Verlag Stuttgart · New York
Estradiol Metabolism During Oral and Transdermal Estradiol Replacement Therapy in Postmenopausal Women
Publikationsverlauf
1997
1998
Publikationsdatum:
20. April 2007 (online)

The metabolism of estradiol was investigated in postmenopausal women after 4 weeks' treatment with oral or transdermal unopposed estradiol. The urinary excretion of the metabolites was examined. With both administration routes, 2-hydroxyestrone, the main A-ring metabolite, and 16α-hydroxyestrone, the main D-ring metabolite, were excreted in higher amounts than estradiol and estrone. The ratio of 2-hydroxyestrone to 16α-hydroxyestrone remained the same for both administration routes. It has been suggested that dominance of D-ring metabolism, i.e. increase of 16α-hydroxyestrone production, is associated with an increased risk of breast cancer. The present study indicates that neither oral nor transdermal estradiol substitution shift this ratio to a higher level of possible risk. Oral estradiol substitution, however, in our study leads to higher metabolite concentrations which may be regarded as hazardous for women with diseases favoring D-ring metabolism.
Key words
Estradiol metabolism - Transdermal and oral estradiol replacement therapy - Postmenopausal women