Mouse Glycine N-Methyltransferase is Sexually Dimorphic and Regulated by Growth Hormone

K. Aida; M. Tawata; M. Negishi; T. Onaya

doi:10.1055/s-2007-978982

Hormone and Metabolic Research, Inhaltsverzeichnis

Horm Metab Res 1997; 29(12): 646-649
DOI: 10.1055/s-2007-978982

Short Communication

Mouse Glycine N-Methyltransferase is Sexually Dimorphic and Regulated by Growth Hormone

K. Aida¹ , M. Tawata¹ , M. Negishi² , T. Onaya¹

¹The Third Department of Internal Medicine, Yamanashi Medical University, Tamaho, Yamanashi, Japan
²Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina, USA

Abstract

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Abstract

The secretion pattern of putuitary growth hormone (GH) in rodents is sexually dimorphic and regulates the expression of some hepatic genes. We report cloning of mouse glycine N-methyltransferase (GNMT) cDNA. The mouse GNMT mRNA is expressed at much lower levels in male than in female livers. Hypophysectomy in male mice resulted in as a high level of the expression as in female mice. Treatment with GH of hypophysectomized male mice twice a day for 5 days decreased the expression. These results indicate that the sex difference of the mouse GNMT expression is regulated by GH secretion patterns.

Key words

Growth Hormone - Mouse Glycine N-methyltransferase - Sexual Dimorphism

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