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Horm Metab Res 1997; 29(12): 646-649
DOI: 10.1055/s-2007-978982
Short Communication

© Georg Thieme Verlag Stuttgart · New York

Mouse Glycine N-Methyltransferase is Sexually Dimorphic and Regulated by Growth Hormone

K. Aida1 , M. Tawata1 , M. Negishi2 , T. Onaya1
  • 1The Third Department of Internal Medicine, Yamanashi Medical University, Tamaho, Yamanashi, Japan
  • 2Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina, USA
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Publication History

1997

1997

Publication Date:
23 April 2007 (online)

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Abstract

The secretion pattern of putuitary growth hormone (GH) in rodents is sexually dimorphic and regulates the expression of some hepatic genes. We report cloning of mouse glycine N-methyltransferase (GNMT) cDNA. The mouse GNMT mRNA is expressed at much lower levels in male than in female livers. Hypophysectomy in male mice resulted in as a high level of the expression as in female mice. Treatment with GH of hypophysectomized male mice twice a day for 5 days decreased the expression. These results indicate that the sex difference of the mouse GNMT expression is regulated by GH secretion patterns.

Key words

Growth Hormone - Mouse Glycine N-methyltransferase - Sexual Dimorphism