Horm Metab Res 1997; 29(2): 63-65
DOI: 10.1055/s-2007-978987
Originals Clinical

© Georg Thieme Verlag Stuttgart · New York

Endogenous and Copper-Induced Lipid Peroxidation and Antioxidant Activity of Serum in Hypercholesterolemic Subjects

G. Mehmetçik, G. Toker, M. Uysal
  • Department of Biochemistry, Istanbul Faculty of Medicine, University of Istanbul, Çapa, Istanbul, Turkey
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Publikationsverlauf

1996

1996

Publikationsdatum:
23. April 2007 (online)

Endogenous malondialdehyde and diene conjugate levels were increased in hypercholesterolemic subjects with serum cholesterol levels above 240 mg/dl as compared to normocholesterolemic subjects (below 20 mg/dl). A decrease in vitamin E/cholesterol and vitamin C/cholesterol ratios was observed in serum of hypercholesterolemic individuals. However, the susceptibility of serum to copper-induced lipid peroxidation and antioxidant activity were found unchanged. The present study indicates that hypercholesterolemic subjects have a high level of circulating lipid peroxides and that a higher tendency towards atherosclerosis in these subjects may be related to increased baseline levels of serum lipid peroxides.