The Calcium/Parathyroid Hormone Regulation in Chronic Renal Failure Investigation of its Dynamic Secretion Pattern

E. Heidbreder; H. Naujoks; U. Brosa; L. Schramm

doi:10.1055/s-2007-978989

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Horm Metab Res 1997; 29(2): 70-75
DOI: 10.1055/s-2007-978989

Originals Clinical

The Calcium/Parathyroid Hormone Regulation in Chronic Renal Failure Investigation of its Dynamic Secretion Pattern

E. Heidbreder¹ , H. Naujoks¹ , U. Brosa² , L. Schramm¹

¹Medizinische Universitätsklinik Würzburg
²Brosa GmbH, Amöneburg, Germany

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Publication History

1996

1996

Publication Date:
23 April 2007 (online)

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In patients with secondary hyperparathyroidism (HPT) caused by chronic renal failure (CRF), the pulsatility of parathyroid hormone (PTH) secretion and the relation of PTH to plasma Ca²⁺ concentrations were investigated. Intermittent hyper- and hypocalcemia was induced to study the deterministic reaction of the parathyroid glands. Compared to normal behaviour in CRF the pulsatility is lost. Yet the deterministic coupling between PTH and Ca²⁺ concentrations remains qualitatively the same though quantitatively it is exaggerated and varies depending on the subjects.

Key words

Parathyroid Hormone Secretion - Hyperparathyroidism - Chronic Renal Failure - Hypocalcemia - Hypercalcemia