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Horm Metab Res 1997; 29(6): 308-310
DOI: 10.1055/s-2007-979041
Symposium Reports

© Georg Thieme Verlag Stuttgart · New York

Islet Regeneration in IFNµ Transgenic Mice

E. M. Jones, N. Sarvetnick
  • The Scripps Research Institute, Department of Immunology, La Jolla, California
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Publication History

1996

1996

Publication Date:
23 April 2007 (online)

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Abstract

The adult pancreas is a developmentally stable organ with limited mitotic activity. This minimal mitotic activity proves critical in insulin-dependent diabetes mellitus (IDDM) since the pathogenesis is characterized by a selective and permanent destruction of islet β cells. The IFNγ transgenic mouse model of islet regeneration elucidates the differentiation pathway involved in the regeneration of functional β cells from ductal precursors and reveals the functional plasticity of the adult pancreas.

Key words

β Cell - Development - Duct Cell - Pancreas - Growth Factors