Effect of Macrophage Colony Stimulating Factor on the Advanced Atherosclerosis in Watanabe Heritable Hyperlipidemic Rabbits

Y. Watanabe; T. Inaba; H. Shimano; T. Gotoda; M. Kawamura; M. Shiomi; Y. Yazaki; N. Yamada

doi:10.1055/s-2007-979090

Subscribe to RSS

Please copy the URL and add it into your RSS Feed Reader.

https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000025.xml

Share / Bookmark

Facebook X Linkedin Weibo

Download PDF

Horm Metab Res 1997; 29(10): 507-509
DOI: 10.1055/s-2007-979090

Originals Clinical

Effect of Macrophage Colony Stimulating Factor on the Advanced Atherosclerosis in Watanabe Heritable Hyperlipidemic Rabbits

Y. Watanabe² , T. Inaba² , H. Shimano² , T. Gotoda² , M. Kawamura² , M. Shiomi¹ , Y. Yazaki² , N. Yamada²

¹Institute for Experimental Animals, Kobe University, School of Medicine, Kobe, Japan
²3rd Department of Internal Medicine, University of Tokyo, Hongo, Tokyo

Further Information

Publication History

1997

1997

Publication Date:
23 April 2007 (online)

Also available at

PDF Download Buy Article Permissions and Reprints

Abstract

We have reported that macrophage colony-stimulating factor (M-CSF) prevents atherosclerosis in young WHHL rabbits (Atherosclerosis 93:245, 1993). In the present study, we injected recombinant human M-CSF (250 µg/day) into WHHL rabbits aged 11 months 3 times a week after advanced atherosclerosis was established. After 8 months of treatment, we did not find any significant difference in plasma lipid levels, cholesterol ester content in the aorta or macroscopic atherosclerosis lesion area between M-CSF treated and non-treated rabbits. There was, however, a significant difference in the ratio of intimal to medial thickness (1.08 vs 1.7, p < 0.01). Thus, M-CSF may influence vascular smooth muscle cell function and modify the process of atherosclerosis in advance lesions.

Key words

M-CSF - Macrophage - Cytokine - Foam Cell - WHHL Rabbit