The effects of 3,5,3'-triiodothyronine (T3) levels on threshold, latency and duration of pentylenetetrazole-induced seizures were tested in rats treated with thyroxine (300 µg/kg · day, N = 9) or methimazole (60 mg/kg · day, N = 5) dissolved in drinking water. Compared to controls (N = 7), methimazole treatment reduced T3 levels (45.4 ± 2.0 vs. 33.0 ± 4.8 ng/dl) and increased seizure duration (36.2 ± 22.4 vs. 289.6 ± 24.4 s) and threshold (29.0 ± vs. 45.5 mg/kg). Thyroxine treatment increased T3 levels (45.4 ± 2.0 vs. 67.7 ± 4.8 ng/dl), but had no significant effect on seizures.
Key words
Triiodothyronine - Thyroxine - Pentylenetetrazole - Seizures
