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Horm Metab Res 1997; 29(12): 639-642
DOI: 10.1055/s-2007-979117
Minisymposium Clinical Research

© Georg Thieme Verlag Stuttgart · New York

Soluble Adhesion Molecules in Type 1 Diabetes Mellitus

S. Martin
  • Diabetes Research Institute at the Heinrich-Heine Universität of Düsseldorf, Germany
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1997

1997

Publikationsdatum:
23. April 2007 (online)

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Abstract

Adhesion molecules play an important role during leukocyte emgration from blood vessels. Furthermore, adhesion molecules are involved in the regulation of the immune system. In addition to membrane-bound adhesion molecules soluble forms have been detected in human serum. During the last few years we have analysed the role of adhesion molecules during the pathogenesis of type I diabetes. This review describes the results of studies on membrane-bound and soluble adhesion molecules in humans and the model of the NOD mouse. Based on these results different adhesion molecule-specific immunotherapies are presented for the prevention of type 1 diabetes and its preclinical stages.

Key words

Soluble ICAM-1 - IDDM - Chronic Inflammation