Tachycardia, Orthostatic Hypotension and Profound Weakness Due to Concomitant Use of Fluoxetine and Nifedipine

T. L. T. Azaz-Livshits; H. D. Danenberg

doi:10.1055/s-2007-979508

Subscribe to RSS

Please copy the URL and add it into your RSS Feed Reader.

https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000054.xml

Share / Bookmark

Facebook X Linkedin Weibo

Download PDF

Pharmacopsychiatry 1997; 30(6): 274-275
DOI: 10.1055/s-2007-979508

Case Reports

Tachycardia, Orthostatic Hypotension and Profound Weakness Due to Concomitant Use of Fluoxetine and Nifedipine

T. L. T. Azaz-Livshits, H. D. Danenberg

Department of Medicine, Clinical Pharmacology Unit, Hadassah University Hospital, Jerusalem, Israel

Further Information

Publication History

Publication Date:
20 April 2007 (online)

Also available at

PDF Download Permissions and Reprints

The use of the selective serotonin reuptake inhibitor fluoxetine is associated with only minor cardiovascular effects. However, due to a possible inhibitory effect on the metabolism of calcium channel blockers it may potentiate the activity of nifedipine, causing profound adverse cardiovascular effects. This report describes the appearance of profound weakness, orthostatic hypotension and tachycardia following the initiation of fluoxetine treatment in a nifedipine-treated 80-year-old patient.