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Pharmacopsychiatry 1996; 29(2): 79-80
DOI: 10.1055/s-2007-979549
Case Report

© Georg Thieme Verlag Stuttgart · New York

Hepatic Failure Associated with Imipramine Therapy

Y. Ilan1 , D. Samuel2 , M. Reynes3 , Ran Tur-Kaspa1
  • 1Liver unit, Division of Medicine, Hadassah University Hospital, Jerusalem, Israel
  • 2Centre Hepato Biliaire, Hôpital Paul Brousse, Paris, France
  • 3Service d'Anatomie pathologique, Hôpital Paul Brousse, Paris, France
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Publication History

Publication Date:
23 April 2007 (online)

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Abstract

Imipramine is an antidepressant drug that is rarely associated with mild liver function abnormalities. These are usually minor and transient liver enzyme elevations which return to normal levels upon discontinuation of the drug. We describe a 48-year-old male who developed subfulminant hepatic failure after imipramine usage, with complete recovery within three months after discontinuation of the drug.