Effects of Calcium Channel Blockers on Steroidogenesis Stimulated by ACTH and cAMP in Isolated Rat Adrenal Cells

M. Matsuki; S. Watanabe; M. Ikeda; S. Nishida; T. Saito

doi:10.1055/s-2007-979818

Hormone and Metabolic Research, Inhaltsverzeichnis

Horm Metab Res 1996; 28(8): 374-376
DOI: 10.1055/s-2007-979818

Originals Basic

Effects of Calcium Channel Blockers on Steroidogenesis Stimulated by ACTH and cAMP in Isolated Rat Adrenal Cells

M. Matsuki¹ , S. Watanabe² , M. Ikeda³ , S. Nishida¹ , T. Saito²

¹Department of Medicine, Kawasaki Medical School, Kurashiki-City, Okayama, Japan
²Department of Pharmacology, Kawasaki Medical School, Kurashiki-City, Okayama, Japan
³Department of Biochemistry, Kawasaki Medical School, Kurashiki-City, Okayama, Japan

Abstract

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Abstract

The effects of the calcium channel blockers verapamil, diltiazem, prenylamine and nifedipine on the ACIH- and cAMP-mediated pathway for steroidogenesis in a suspension solution of isolated rat adrenal cells were studied. Steroidogenesis stimulated by ACIH (10^-10 M) or cAMP (10^-3 M) was not inhibited by nifedipine (10^-4 M), but was strongly inhibited in a concentration-dependent manner by verapamil, diltiazem and prenylamine (10^-5 to 10^-4 M).

Key words

Rat Adrenal Cell - Ca Channel Blocker - ACTH - cAMP - Steroidogenesis

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