In Vitro and In Vivo Effects of Somatostatin on the Growth of A431 Cells

Y. Kamiya; Junko Ito; T. Fujii; K. Horie; M. Kawaguchi; Reiko Hori; N. Sakuma; T. Fujinami

doi:10.1055/s-2007-979934

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 1995; 27(4): 179-181
DOI: 10.1055/s-2007-979934

Originals Basic

In Vitro and In Vivo Effects of Somatostatin on the Growth of A431 Cells

Y. Kamiya, Junko Ito, T. Fujii, K. Horie, M. Kawaguchi, Reiko Hori, N. Sakuma, T. Fujinami

Third Department of Internal Medicine, Nagoya City University Medical School, Nagoya, Japan

Abstract

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Abstract

We previously reported that the octapeptide somatostatin (SS) analogue SMS 201-995 (SMS) unexpectedly stimulates the growth of A431 human epidermoid carcinoma cells in vitro. In the present study, we found that both SS-14 and SS-28 also stimulated the growth of A431 cells in vitro. The proliferative effect of SS-28 also stimulated the growth of A431 cells in vitro. The proliferative effect of SS-28 was greater than that of SS-14. In contrast, there was no difference in A431 cell tumor weight or area between the SMS-treated or untreated athymic, tumor-bearing mice. The serum epidermal growth factor (EGF) level of the SMS-treated mice was significantly lower than that of the untreated mice. Decreases in serum EGF may attenuate the proliferative effect of SMS in vivo.

Key words

Somatostatin - A431 Cells - Athymic Nude Mice - SMS 201-995 - Epidermal Growth Factor

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