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DOI: 10.1055/s-2007-980066
Das „benigne” metastasierende Leiomyom
Fallsammlung und therapeutische OptionenThe Benign Metastasizing LeiomyomaCase Collection and Therapeutical OptionsPublikationsverlauf
eingereicht 30.1.2007
akzeptiert 30.4.2007
Publikationsdatum:
10. Juli 2007 (online)

Zusammenfassung
Wir berichten über 2 Patientinnen mit beidseitigen Lungenrundherden als Zufallsbefund. Eine videoassistierte thorakoskopische Exploration erbrachte die histopathologische Diagnose eines „benignen” metastasierenden Leiomyoms (BML). Ursprung und Dignität dieser Erkrankung sind nicht eindeutig geklärt. Wir diskutieren hier die Ursache des Krankheitsbildes und die möglichen Therapieoptionen - von der Ovarektomie bis zu verschiedenen Hormontherapien, ohne dass eine einheitliche Therapieempfehlung gegeben werden kann.
Abstract
We report two patients with pulmonary nodules detected by chance. Histopathology of biopsies retrieved by surgical videothoracoscopy revealed benign metastasizing leiomyoma (BML). The origin of this disease as well as its dignity are not fully understood. We discuss the origin of this disease and different therapeutic options - from oophorectomy to different hormon therapies. A standardized therapeutic recommendation cannot be given.
Literatur
- 1
Bell S W, Kempson R L, Hendrickson M R.
Problematic uterine smooth muscle neoplasms. A clinicopathologic study of 213 cases.
Am J Surg Pathol.
1994;
18
535-558
MissingFormLabel
- 2
Steiner P E.
Metastasizing fibroleiomyoma of the uterus. Report of a case and review of the literature.
Am J Pathol.
1939;
15
89-109
MissingFormLabel
- 3
Patton K T, Cheng L, Papavero V. et al .
Benign metastasizing leiomyoma: clonality, telomere length and clinicopathologic analysis.
Modern Pathology.
2006;
19
130-140
MissingFormLabel
- 4
Wolff M, Silva F, Kaye G.
Pulmonary metastases (with admixed epithelial elements) from smooth muscle neoplasms.
Report of nine cases, including three males.
Am J Surg Pathol.
1979;
3
325-342
MissingFormLabel
- 5
Cramer S F, Meyer J S, Kraner J F. et al .
Metastasizing leiomyoma of the uterus. S-phase fraction, estrogen receptor and ultrastructure.
Cancer.
1980;
45
932-937
MissingFormLabel
- 6
Abell M R, Littler E R.
Benign metastasizing uterine leiomyoma. Multiple lymph nodal metastases.
Cancer.
1975;
36
2206-2213
MissingFormLabel
- 7
Horiuchi K, Yabe H, Mukai M. et al .
Multiple smooth muscle tumors arising in deep tissue of lower limbs with uterine leiomyomas.
Am J Surg Pathol.
1998;
22
897-901
MissingFormLabel
- 8
Cho K R, Woodruff J D, Epstein J I.
Leiomyoma of the uterus with multiple extrauterine smooth muscle tumors: a case report
suggesting multifocal origin.
Human Pathol.
1989;
20
80-83
MissingFormLabel
- 9
Sentinelli S, Covello R, Benevolo M. et al .
Benign metastasizing pulmonary leiomyoma: description of a case and review of the
literature.
Pathologica.
2002;
94
253-256
MissingFormLabel
- 10
Evans A J, Wiltshaw E, Kochanowski S J. et al .
Metastasizing leiomyoma of the uterus and hormonal manipulations. Case report.
Br J Obstet Gynaecol.
1986;
93
646-648
MissingFormLabel
- 11
Alessi G, Lemmerling M, Vereecken L. et al .
Benign metastasizing leiomyoma to skull base and spine: a report of two cases.
Clin Neurol Neurosurg.
2003;
105
170-174
MissingFormLabel
- 12
Giove S, Scappaticci E, Baldi S. et al .
Benign metastasizing uterine leiomyoma. Case report.
Minerva Med.
1984;
75
1819-1821
MissingFormLabel
- 13
Nakanishi S, Nakano K, Hiramoto T. et al .
So-called benign metastasizing leiomyoma of the lung presenting with bone metastases.
Nihon Kokyuki Gakkai Zasshi.
1999;
37
146-150
MissingFormLabel
- 14
Takemura G, Takatsu Y, Kaitani K. et al .
Metastasizing uterine leiomyoma. A case with cardiac and pulmonary metastasis.
Pathol Res Pract.
1996;
192
622-629
MissingFormLabel
- 15
Arai T, Yasuda Y, Takaya T. et al .
Natural Decrease of Benign Metastasizing Leiomyoma.
Chest.
2000;
117
921-922
MissingFormLabel
- 16
Horstmann J P, Pietra G G, Harman J A. et al .
Spontaneous regression of pulmonary leiomyomas during pregnancy.
Cancer.
1977;
39
314-321
MissingFormLabel
- 17
Banner A S, Carrington C B, Emory W B. et al .
Efficacy of oophorectomy in lymphangioleiomyomatosis and benign metastasizing leiomyoma.
N Engl J Med.
1981;
305
204-209
MissingFormLabel
- 18
Esteban J M, Allen W M, Schaerf R H.
Benign metastasizing leiomyoma of the uterus. Histologic and immunohistochemical characterization
of primary and metastatic lesions.
Arch Pathol Lab Med.
1999;
123
960-962
MissingFormLabel
- 19
Jautzke G, Müller-Ruchholtz E, Thalmann U.
Immunohistological detection of estrogen and progesterone receptors in multiple and
well differentiated leiomyomatous lung tumors in women with uterine leiomyomas (so-called
benign metastasizing leiomyomas). A report on 5 cases.
Pathol Res Pract.
1996;
192
215-223
MissingFormLabel
- 20
Pawlik C, Wildberger J E, Tietze L. et al .
Benign metastasizing leiomyoma of the lung-a rare differential diagnosis of pulmonary
space-occupying lesions.
Dtsch Med Wochenschr.
2001;
126
551-555
MissingFormLabel
- 21
Uchida T, Nakakawaji K, Sakamoto J. et al .
The effectiveness of medroxyprogesterone in the treatment of multiple metastasizing
leiomyosarcomas: report of a case.
Surg Today.
1996;
26
138-141
MissingFormLabel
- 22
Cohen J D, Robins H I.
Response of “benign” metastasizing leiomyoma to progestin withdrawal.
Eur J Gynaecol Oncol.
1993;
1
44-45
MissingFormLabel
- 23
Rivera J A, Christopoulos S, Small D. et al .
Hormonal manipulation of benign metastasizing leiomyomas: report of two cases and
review of the literature.
J Clin Endocrinol Metab.
2004;
89
3183-3188
MissingFormLabel
- 24
Jacobson T Z, Rainey E J, Turton C WG.
Pulmonary benign metastasizing leiomyoma: response to treatment with goserilin.
Thorax.
1995;
50
1225-1226
MissingFormLabel
- 25
Abramson S, Gilkeson R C, Goldstein J D. et al .
Benign metastasizing leiomyoma: clinical, imaging and pathologic correlation.
Am J Roent.
2001;
176
1409-1413
MissingFormLabel
- 26
Kayser K, Zink S, Schneider T. et al .
Benign matastasizing leiomyoma of the uterus: documentation of clinical, immunohistochemical
and lectin-histochemical data of ten cases.
Virchows Arch.
2000;
437
284-292
MissingFormLabel
- 27
Maheux R, Samson Y, Farid N R. et al .
Utilization of luteinizing hormone-releasing hormone agonist in pulmonary leiomyomatosis.
Fertil Steril.
1987;
48
315-317
MissingFormLabel
- 28
Winkler T R, Burr L H, Robinson C L.
Benign metastasizing leiomyoma.
Ann Thorac Surg.
1987;
43
100-101
MissingFormLabel
- 29
Motegi M, Takayanagi N, Sando Y. et al .
[A case of so-called benign metastasizing leiomyoma responsive to progesterone].
Nihon Kyobu Shikkan Gakkai Zasshi.
1993;
31
890-895
MissingFormLabel
- 30
Nishida T, Inoue K, Yamamoto R. et al .
[Case of benign metastaxsizing leiomyoma of the lungs].
Nippon Kyobu Geka Gakkai Zasshi.
1996;
44
182-187
MissingFormLabel
- 31
Mikami I, Yamamoto M, Nishimura H. et al .
[Multiple lungs tumors found 17 years after hysterectomy - a case of benign metastasizing
leiomyoma].
Jpn J Thorac Cardiovasc Surg.
1998;
46
634-638
MissingFormLabel
- 32
Kadry M, Sievers C, Engelmann C.
Benign metastasizing leiomyoma of the uterus: documentation of clinical, immunohistochemical
and lectin-histochemical data of ten cases.
Acta Chir Hung.
1999;
38
57-61
MissingFormLabel
- 33
Koh D M, Burn P R, King D M.
Benign metastasizing leiomyoma with intracaval leiomyomatosis.
Br J Radiol.
2000;
73
435-437
MissingFormLabel
- 34
Abramson S, Gilkeson R C.
Multiple pulmonary nodules in an asymptomatic patient.
Chest.
1999;
116
245-247
MissingFormLabel
- 35
Sabatini R, Ferreri R, Distante G. et al .
Benign metastasizing leiomyoma in the lung: a case report.
Eur J Gynaecol Oncol.
2002;
23
445-446
MissingFormLabel
- 36
Nardo L G, Iyer L, Reginald P W.
Benign pulmonary metastasizing leiomyomatosis in pregnancy: a rare complication after
cesarean section.
Acta Obstetricia et Gynecologica Scandinavica.
2003;
82
770
MissingFormLabel
- 37
Hashizume T, Fujimoto H.
[Benign metastasizing leiomyoma from uterine myoma; report of a case].
Kyobu Geka.
2004;
57
164-167
MissingFormLabel
- 38
Wentling G K, Sevin B U, Geiger X J. et al .
Benign metastasizing leiomyoma responsive to megestrol: case report and review of
the literature.
Int J Gynecol Cancer.
2005;
15
1213-1217
MissingFormLabel
- 39
Chan J W, Law W L, Cheung S OY. et al .
Benign metastasising leiomyoma: a rare but possible cause of bilateral pulmonary nodules
in Chinese patients.
Hong Kong Med J.
2005;
11
303-306
MissingFormLabel
- 40
Benetti-Pinto C L, Soares P M, Petta C A. et al .
Pulmonary benign metastasizing leiomyoma: a report of 2 cases with different outcomes.
J Reprod Med.
2006;
51
715-718
MissingFormLabel
- 41
Kwon Y I, Kim T H, Sohn J W. et al .
Benign pulmonary metastasizing leiovomatosis: case report and a review of the literature.
Korean J Intern Med.
2006;
21
173-177
MissingFormLabel
- 42
Ishibashi H, Ohta S, Hirose M. et al .
[Pulmonary benign metastasizing leiomyoma from uterine myoma; report of a case].
Kyobu Geka.
2006;
59
951-954
MissingFormLabel
- 43
Arif S, Ganesan R, Spooner D.
Intravascular leiomyomatosis and benign metastasizing leiomyoma: an unusual case.
Int J Gynecol Cancer.
2006;
16
1448-1450
MissingFormLabel
- 44
Egberts J H, Schafmayer C, Bauerschlag D O. et al .
Benign abdominal and pulmonary metastasizing leiomyoma of the uterus.
Arch Gynecol Obstet.
2006;
274
319-322
MissingFormLabel
Dr. med. Andreas Bastian
Thoraxzentrum Ruhrgebiet, Standort Bochum, Klinik für Pneumologie und Infektiologie,
Augusta-Kranken-Anstalt
Bergstr. 26
44789 Bochum
eMail: andreas.bastian@rub.de