Planta Med 2007; 73(8): 787-791
DOI: 10.1055/s-2007-981549
Natural Product Chemistry
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Two New Quaternary Alkaloids and Anti-Hepatitis B Virus Active Constituents from Corydalis saxicola

Ying-Rui Wu1 , 2 , Yun-Bao Ma1 , You-Xing Zhao1 , Shu-Ying Yao1 , 2 , Jun Zhou1 , Ying Zhou3 , Ji-Jun Chen1
  • 1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
  • 2Graduate School of Chinese Academy of Sciences, Beijing, P. R. China
  • 3Guangxi Institue of Chinese Medicine & Pharmaceutical Science, Nanning, P. R. China
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Publikationsverlauf

Received: February 26, 2007 Revised: May 17, 2007

Accepted: May 21, 2007

Publikationsdatum:
05. Juli 2007 (online)

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Abstract

Two new quaternary isoquinoline alkaloids, saxicolalines A (1) and N-methylnarceimicine (2), together with sixteen known alkaloids (3 - 18) were isolated from Corydalis saxicola Bunting. The structures of saxicolalines A (1) and N-methylnarceimicine (2) were established based on spectral methods including 1D, 2D NMR (COSY, HMQC, HMBC) and HR-ESI-MS. The anti-HBV activities of ten main alkaloids were evaluated. Among the tested compounds, dihydrochelerythrine (8) exhibited the most potent activity against HBsAg and HBeAg secretions with IC50 < 0.05 μM, SI > 3.5, respectively.