Gender Specific Correlations of Adrenal Gland Size and Body Fat Distribution: A Whole Body MRI Study

Abstract

Objective: The aim of this study was to investigate the gender specific correlations of stress related tissues [adrenal gland volume (AV), visceral fat] and alimentary dependent fat compartments with cortisol concentrations in healthy male and female subjects.

Methods: Fourteen men and 13 women were examined. Fat compartments [whole body fat, visceral adipose tissue (VAT) and subcutaneous adipose tissue (SCAT)] were determined using whole body MRI. Adrenal gland volume was assessed by a 3D MR data set. The salivary cortisol was determined at 9 AM and 4 PM.

Results: Men had significantly more visceral fat and less subcutaneous fat than women. Adrenal gland size correlated significantly with the visceral and subcutaneous fat in women (r=0.7, p=0.008), but not in men (r=0.2, p=0.4). There was a negative correlation between the decrease of cortisol between 9 AM and 4 PM with VAT (r=-0.451, p=0.027) in the whole group.

Discussion: The high correlation between the adrenal gland volume and VAT in women underlines the link between hypothalamic-pituitary-adrenal (HPA) axis, stress, and circadian cortisol rhythm, respectively, and an increased abdominal fat volume. The lack of correlation between visceral fat and adrenal volume in men points to an additional influence of sex hormones.

Adrenal gland volume - cortisol - visceral adipose tissue

References

• 1 Lebowitz E, Banerji MA. Point: Visceral adiposity is causally related to insulin resistance.  Diabetes Care. 2005;  28 2322-2325
• 2 Machann J, Thamer C, Schnoedt B, Haap M, Haring HU, Claussen CD, Stumvoll M, Fritsche A, Schick F. Standardized assessment of whole body adipose tissue topography by MRI.  J Magn Reson Imaging. 2005;  21 455-462
• 3 Fasshauer M, Klein J, Blüher M, Paschke R. Adipocytokines: Possible link between insulin resistance and obesity.  Dtsch Aerztebl. 2004;  101 3491-3495
• 4 Lamounier-Zepter V, Ehrhart-Bornstein M, Bornstein SR. Metabolic syndrome and the endocrine stress system.  Horm Metab Res. 2006;  38 437-441
• 5 Nemeroff CB, Krishnan KRR, Reed D, Leder R, Beam C, Dunnik NR. Adrenal gland enlargement in major depression. A computed tomographic study.  Arch Gen Psychiatry. 1992;  49 384-387
• 6 Rubin RT, Phillips JJ, Sadow TF, MacCracken JT. Adrenal gland volume in major depression. Increase during the depressive episode and decrease with successful treatment.  Arch Gen Psychiatry. 1995;  52 213-218
• 7 Weber-Hamann B, Hentschel F, Kniest A, Deuschle M, Colla M, Lederbogen F, Heuser I. Hypercortisolemic depression is associated with increased intra-abdominal fat.  Psych Med. 2002;  64 274-277
• 8 Dressendörfer RA, Kirschbaum C, Rohde W, Stahl F, Strasburger CJ. Synthesis of a cortisol-biotin conjugate and evaluation as a tracer in an immunoassay for salivary cortisol measurement.  J Steroid Biochem Mol Biol. 1992;  43 683-692
• 9 Hauner H, Entenmann G, Wabitsch M, Gaillard D, Ailhaud G, Negrel R, Pfeiffer EF. Promoting effect of glucocorticoids on the differentiation of human adipocyte precursor cells cultured in a chemically defined medium.  J Clin Invest. 1989;  84 1663-1670
• 10 Bjorntorp P. The regulation of adipose tissue distribution in humans.  Int J Obes Relat Metab Disord. 1996;  20 291-302
• 11 Ahima RS. Adipose tissue as an endocrine organ.  Obesity (Silver Spring). 2006;  14 ((Suppl 5)) 242S-249S
• 12 Purnell JQ, Brandon DD, Isabelle LM, Loriaux DL, Samuels MH. Association of 24-hour cortisol production rates, cortisol-binding globulin, and plasma-free cortisol levels with body composition, leptin levels, and aging in adult men and women.  J Clin Endocrinol Metab. 2004;  89 281-287
• 13 Schommer NC, Hellhammer DH, Kirschbaum C. Dissociation between reactivity of the hypothalamus-pituitary-adrenal axis and the sympathetic-adrenal-medullary system to repeated psychosocial stress.  Psychosom Med. 2003;  65 450-460
• 14 Federenko IS, Nagamine M, Hellhammer DH, Wadhwa PD, Wust S. The heritability of hypothalamus pituitary adrenal axis responses to psychosocial stress is context dependent.  J Clin Endocrinol Metab. 2004;  89 6244-6250
• 15 Marniemi J, Kronholm E, Aunola S, Toikka T, Mattlar CE, Koskenvuo M, Ronnemaa T. Visceral fat and psychosocial stress in identical twins discordant for obesity.  J Intern Med. 2002;  251 35-43
• 16 Bhasin S. Effects of testosterone administration on fat distribution, insulin sensitivity, and atherosclerosis progression.  CID. 2003;  37 ((Suppl 2)) 142-149
• 17 Rissanen J, Hudson R, Ross R. Visceral adiposity, androgens, and plasma lipids in obese men.  Metabolism. 1994;  43 1318-1323
• 18 Bronnegard M, Arner P, Hellstrom L, Akner G, Gustafsson JA. Glucocorticoid receptor messenger ribonucleic acid in different regions of human adipose tissue.  Endocrinology. 1990;  127 1689-1696

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