RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000084.xml
Synthesis 2007(12): 1765-1767
DOI: 10.1055/s-2007-983710
DOI: 10.1055/s-2007-983710
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York
An Approach to Amino Ester Subunits of Tamiflu
Weitere Informationen
Received
30 March 2007
Publikationsdatum:
08. Juni 2007 (online)
Publikationsverlauf
Publikationsdatum:
08. Juni 2007 (online)
![](https://www.thieme-connect.de/media/synthesis/200712/lookinside/thumbnails/10.1055-s-2007-983710-1.jpg)
Abstract
A two-step synthesis of amino cyclohexene carboxylic acid esters has been achieved in good overall yield from nitro phosphonate and unsaturated aldehydes.
Key words
Tamiflu - Michael addition - ring closure
- 1
De Clercq E. Curr. Opin. Microbiol. 2005, 8: 552 - 2
Oxford JS.Bossuyt S.Balasingam S.Mann A.Novelli P.Lambkin R. Clin. Microbiol. Infect. 2003, 9: 1 -
3a
Abrecht S.Harrington P.Iding H.Karpf M.Trussardi R.Wirz B.Zutter U. Chimia 2004, 58: 621 -
3b
Ward P.Small I.Smith J.Suter P.Dutkowski R. J. Antimicrob. Chemother. 2005, 55 (Suppl. 1): i5 -
4a For the Corey route, see:
Yeung Y.-Y.Hong S.Corey EJ. J. Am. Chem. Soc. 2006, 128: 6310 - For the Shibasaki route, see:
-
4b
Fukuta Y.Mita T.Fukuda N.Kanai M.Shibasaki M. J. Am. Chem. Soc. 2006, 128: 6312 -
4c
Yamatsugu K.Kamijo S.Suto Y.Kanai M.Shibasaki M. Tetrahedron Lett. 2007, 48: 1403 -
4d
Mita T.Fukuda N.Roca FX.Kanai M.Shibasaki M. Organic Lett. 2007, 9: 259 - 5
Krishnamoorthy G.Webb S.Nguyen T.Chowdhury PK.Halder M.Wills NJ.Carpenter S.Kraus GA.Gordon MS.Petrich JW. Photochem. Photobiol., A 2005, 81: 924 - 6
Martyres DH.Baldwin JE.Adlington RM.Lee V.Probert MR.Watkin DJ. Tetrahedron 2001, 57: 4999 - 7
Kleschick W.Heathcock CH. J. Org. Chem. 1978, 43: 1256 - 8
Kahnberg P.Lager E.Rosenberg C.Schougaard J.Camet L.Sterner O.Nielsen EO.Nielsen M.Liljefors T. J. Med. Chem. 2002, 45: 4188 - 9
Schaefer JP. J. Org. Chem. 1960, 2027