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Synthesis 2007(12): 1823-1826
DOI: 10.1055/s-2007-983720
DOI: 10.1055/s-2007-983720
PAPER
© Georg Thieme Verlag Stuttgart · New York
A Highly Efficient and Useful Synthetic Protocol for the Synthesis of Bis[aryl(diethoxyphosphoryl)methyl]amines from Aromatic Aldehydes Using Acetyl Chloride as an Efficient Catalyst
Weitere Informationen
Received
6 March 2007
Publikationsdatum:
08. Juni 2007 (online)
Publikationsverlauf
Publikationsdatum:
08. Juni 2007 (online)
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Abstract
A highly efficient and useful method for the synthesis of bis[aryl(diethoxyphosphoryl)methyl]amines has been developed. The treatment of aromatic aldehydes with ammonia followed by reaction with diethyl phosphite in the presence of acetyl chloride as catalyst gives bis[aryl(diethoxyphosphoryl)methyl]amines. This method is easy, rapid, and a high yielding method for the synthesis of bis[aryl(diethoxyphosphoryl)methyl]amines with good diastereoselection from simple starting materials.
Key words
acetyl chloride - diethyl phosphite - aldehyde - bis[aryl(diethoxyphosphoryl)methyl]amine - addition reaction
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