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Synthesis 2007(18): 2920-2923
DOI: 10.1055/s-2007-983799
DOI: 10.1055/s-2007-983799
PSP
© Georg Thieme Verlag Stuttgart · New York
Preparation of Enantioenriched Axially Chiral Anilides via [2+2+2] Cycloaddition of 1,6-Diynes with Trimethylsilylynamides
Further Information
Received
8 March 2007
Publication Date:
12 July 2007 (online)
Publication History
Publication Date:
12 July 2007 (online)
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Abstract
The rhodium-catalyzed enantioselective [2+2+2] cycloaddition of 1,6-diynes with trimethylsilylynamides provides enantioenriched axially chiral anilides in poor to good yields with good to excellent enantioselectivity. Trimethylsilylynamides can be readily prepared in two steps starting from commercially available bis(trimethylsilyl)acetylene.
Key words
anilides - diynes - BINAP - rhodium - ynamides
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