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Synthesis 2007(17): 2653-2659
DOI: 10.1055/s-2007-983816
DOI: 10.1055/s-2007-983816
PAPER
© Georg Thieme Verlag Stuttgart · New York
N-Methylimidazole as a Promising Catalyst for the Aza-Michael Addition Reaction of N-Heterocycles
Further Information
Received
25 April 2007
Publication Date:
24 July 2007 (online)
Publication History
Publication Date:
24 July 2007 (online)
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Abstract
N-Methylimidazole has been shown to be a promising catalyst for aza-Michael reactions. Various N-heterocycles were introduced to α,β-unsaturated carbonyl compounds employing N-methylimidazole (0.05 equiv) in a highly efficient, rapid and high yielding synthesis of N-heterocyclic derivatives.
Key words
N-methylimidazole - Michael additions - nucleophiles - heterocycles - α,β-unsaturated compounds
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