A Conjugate Reduction Pathway to Chiral Silanes Using CuH

Bruce H. Lipshutz; Ching-Tien Lee; Benjamin R. Taft

doi:10.1055/s-2007-983830

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A Conjugate Reduction Pathway to Chiral Silanes Using CuH

Bruce H. Lipshutz*, Ching-Tien Lee, Benjamin R. Taft
Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, USA
Fax: +1(805)8938265; e-Mail: Lipshutz@chem.ucsb.edu;

Abstract

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Abstract

Experimental details concerning asymmetric 1,4-reduction of β-silylated-β,β-disubstituted enoates catalyzed by CuH are described. High yields and enantiomeric excesses are to be expected when Solvias’ JOSIPHOS bis-phosphine PPF-P(t-Bu)₂ is used as a nonracemic ligand.

Key words

chiral silanes - CuH - asymmetric conjugate reduction

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References

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