Covalently Anchored Sulfonic Acid on Silica Gel as an Efficient and Reusable Heterogeneous Catalyst for the One-Pot Synthesis of Hantzsch 1,4-Dihydropyridines under Solvent-Free Conditions

Raman Gupta; Rajive Gupta; Satya Paul; Andre Loupy

doi:10.1055/s-2007-983839

PAPER

Covalently Anchored Sulfonic Acid on Silica Gel as an Efficient and Reusable Heterogeneous Catalyst for the One-Pot Synthesis of Hantzsch 1,4-Dihydropyridines under Solvent-Free Conditions

Raman Gupta^a, Rajive Gupta^a, Satya Paul*^a, Andre Loupy^b
^a Department of Chemistry, University of Jammu, Jammu-180 006, India
Fax: +91(191)2505086; e-Mail: paul7@rediffmail.com;
^b Laboratoire des Reactions Sélectives sur Supports, Paris-South University, 91405 Orsay cedex, France
e-Mail: andre.loupy@cegetel.net;

Abstract

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Abstract

A highly efficient one-pot synthesis of Hantzsch 1,4-dihydropyridines under solvent-free conditions catalyzed by sulfonic acid covalently anchored onto the surface of silica gel is reported here. All types of aldehydes, including aromatic, unsaturated, and heterocyclic aldehydes, gave excellent yields. The silica gel/sulfonic acid catalyst (SiO₂-SO₃H) is completely heterogeneous and can be recycled for eight consecutive runs without significant loss of activity.

Key words

1,3-dicarbonyl compounds - supported catalysis - 1,4-dihydropyridines - heterogeneous catalysis - solvent-free conditions

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